THE BEST SIDE OF PKRRATING

The activated enzyme then phosphorylates its main substrate, the translational initiation factor eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to your conserved relatives of four protein kinases (PKR, PERK, GCN2, HRI) that each one phosphorylate eIF2α in reaction to various stimuli12, triggering the built-in worr